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KMID : 0942820090080020131
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 2 p.131 ~ p.137
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Clinical Analysis of Treatment in the Intracranial Hemangioblastomas
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Kim Ho-Sang
Cho Won-Ho
Hur Byeong-Ik
Kang Dong-Wan
Cha Seung-Heon
Choi Chang-Hwa
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Abstract
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Objective: Intracranial hemangioblastomas are benign vascular tumors arising either sporadically or as a manifestation of von Hippel-Lindau(VHL) disease. We analysed a series of patients with intracranial hemangioblastoma to review our strategy of treatment.
Materials and Methods: Consecutive patients with intracranial hemangioblastoma who underwent surgery and then adjuvant therapy if needs, at our institute. Eighteen patients(14 female and 4 male patients) underwent 21 operations for removal of 19 intracranial hemangioblastoma(age at surgery 45±9.2 years, follow-up duration 37±8 months). Serial clinical examinations, imaging studies, and operative records were analyzed.
Results: Twelve patients(66%) had sporadic hemangioblastomas. And six patients(34%) were von Hippel-Lindau disease. Symptoms and signs included headache(64.7%), dizziness(64.7%), gait disturbance(20%), and hydrocephalus(56%). Total resection rate was 71%(15/21). Six patients whose tumor were partially removed. Adjuvant radiosurgery was performed to 6 patients. Four patients of them were stabilized after radiosurgery. Two cystic hemangioblastoma cases were aggravated in the size of cystic portion, so revision were performed. Preoperative tumor embolization was performed in 2 cases. One VHL patient was expired due to pheochromocytoma.
Conclusion: Symptoms and signs caused by intracranial hemangioblastoma can be treated safely and effectively with surgical resection. Radiosurgery may be adequate adjuvant therapy for remnant intracranial hemangioblastoma except cystic hemangioblastomas.
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KEYWORD
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Hemangioblastoma, Radiosurgery, Gamma knife
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